PHYS30250 Haemostasis and Thrombosis

Academic Year 2022/2023

The integrity of the cardiovascular system and the prevention of blood loss are essential for normal body function. 'Haemostasis' is the physiological process of stopping bleeding after tissue injury, whereas 'Thrombosis' refers to pathological clot formation resulting in serious clinical consequences such as myocardial infarction, stroke, and pulmonary embolism.
The module allows students to deepen their understanding of the mechanisms underlying these processes and it provides a foundation for research in the areas of Haemostasis and Thrombosis.

This module is intended mainly for students in stage 4 of the Science degree programme, the Biomedical Health and Life Science programme and medical students who have completed stage 2 of their degree. Other students with an appropriate learning background are also welcome but should discuss this with the module coordinator before enrolling.

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Curricular information is subject to change

Learning Outcomes:

On successful completion of this module students will understand the mechanisms underlying haemostasis and thrombosis, the control of vascular intactness, the regulation of blood platelets, the clotting cascade, the fibrinolytic system and the role of the endothelium. Students will also be able to describe and discuss some clinically important disorders of haemostasis.

Indicative Module Content:

Components of blood and the structure of the vascular wall are revised. The biogenesis, structure and function of platelets are described. Molecular signalling networks including the nitric oxide and prostacyclin pathways, and the role of platelets in the separation of lymphatic and blood vessels are discussed. The clotting cascade and the fibrinolytic pathway and their regulation are outlined. Interactions between clotting factors, platelets, and the vascular wall are highlighted. The origins of various bleeding and thrombotic disorders are discussed. Methods to assess platelet, clotting, and vascular function are described. Thrombotic disorders of veins and arteries are presented. Original research papers are used to highlight recent advances and controversies in the field.

Student Effort Hours: 
Student Effort Type Hours
Lectures

14
Tutorial

4
Specified Learning Activities

37
Autonomous Student Learning

50
Total

105
Approaches to Teaching and Learning:
Students are guided along a learning pathway through lectures, tutorials and online material. Various types of assessment will help to ensure the achievement of learning outcomes. 
Requirements, Exclusions and Recommendations
Learning Requirements:

Other suitable prior learning that has outcomes similar to those of PHYS30010 or MDSA20170/MDSA10090 may substitute. Please discuss with module coordinator for further information.

Learning Recommendations:

PHYS30010 or MDSA20170


Module Requisites and Incompatibles
Pre-requisite:
MDSA20170 - Vascular Biology, PHYS30010 - Cardiovascular Physiology

Additional Information:
Other suitable prior learning that has outcomes similar to those of PHYS30010 or MDSA20170/MDSA10090 may substitute. Please discuss with module coordinator for further information.


 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Continuous Assessment: Quiz 3 Varies over the Trimester n/a Standard conversion grade scale 40% No

15
Continuous Assessment: Quiz 2 Varies over the Trimester n/a Standard conversion grade scale 40% No

15
Assignment: Review essay 1 based on selected original research publications Varies over the Trimester n/a Graded No

20
Assignment: Review essay 2 based on selected original research publications Varies over the Trimester n/a Graded No

20
Presentation: Presentation 1 Varies over the Trimester n/a Graded No

8
Presentation: Presentation 2 Varies over the Trimester n/a Graded No

8
Continuous Assessment: Quiz 1 Varies over the Trimester n/a Standard conversion grade scale 40% No

15

Carry forward of passed components
No
 
Resit In Terminal Exam
Spring No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
• Online automated feedback

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Professor Cormac Taylor Lecturer / Co-Lecturer
Dr Julie Freeman Tutor