PERS30020

This module forms part of the core curriculum for the BSc degree in Health and Performance Science at Stage 3. It may be taken as an option for Biochemistry, Pharmacology or Physiology BSc students at stage 3 or 4. The molecular biology of exercise represents a new vista in the sport and exercise sciences, with an increasing acknowledgement that discoveries made on the bench-top have wide-ranging implications in the efficacy and application of exercise and training in health and disease. This module explores the molecular biology that underpins the many metabolic effects of exercise and adaptations to exercise. Beginning with an introduction to molecular exercise science and key concepts, the pathways that regulate the acute response to aerobic and resistance exercise and the nature of adaptation to training are then explored. Special reference is given to skeletal muscle, but other organs are also considered. This information is later discussed in relation to the relevance of these pathways in biological adaptation in health and disease, particularly in the context of insulin resistance and lifestyle-related chronic disease. In addition, genetics, sport and exercise and ‘omics’ strategies (nutrigenomics, metabolomics and proteomics) – a rapidly emerging multidisciplinary field - in health and exercise science are introduced.