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PATH30260

Academic Year 2024/2025

Oncology and Rheumatology (PATH30260)

Subject:
Pathology
College:
Health & Agricultural Sciences
School:
Medicine
Level:
3 (Degree)
Credits:
5
Module Coordinator:
Dr Stephen Lalor
Trimester:
Spring
Mode of Delivery:
On Campus
Internship Module:
No
How will I be graded?
Letter grades

Curricular information is subject to change.

The Oncology and Rheumatology Module (PATH30260) reviews the biochemical and molecular processes underlying neoplastic, rheumatic and allergic diseases, and the pharmacologic agents used to intervene in these processes through lectures, tutorials and online British Medical Journal (BMJ) tutorial submissions.

This module covers the basic pathology of cancer to include tumour classification and terminology, invasion and metastasis and molecular carcinogenesis. The pathology of tumours of the breast, bone and soft tissues, the skin (malignant melanoma and non-melanoma skin cancers) and childhood tumours are included, as are chemotherapeutic and biotherapeutic agents, including targeted therapies, monoclonal antibody therapies and an introduction to the care of the patient with cancer, including the management of side effects of chemotherapy.

Immunopathology processes are reviewed with special emphasis being placed on the mechanisms underlying hypersensitivity reactions, autoimmunity, transplantation and rejection. In addition, the clinical presentation, pathology and treatment of systemic autoimmune diseases (including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis and various systemic vasculitides) are discussed. The pharmacology of anti-inflammatory and immunosuppressive agents are introduced.

The clinical presentation, behaviour and pharmacological management of these inflammatory, immunologic and neoplastic diseases are introduced together with clinicopathological correlation and elementary planning and evaluation of treatment through lectures and tutorials.

About this Module

Learning Outcomes:

On successful completion of the module, students should have:

1. Improved their biomedical knowledge by being able to:
(a) Understand the principles of tumour classification and terminology, tumour characteristics and tumour progression
(invasion and metastasis).
(b) Outline the causes of cancer including viral, chemical and physical carcinogenesis and hereditary predisposition.
(c) Outline and discuss the biochemical, molecular and genetic basis (oncogenes/tumour suppressor genes) of neoplasia and
the points of possible therapeutic intervention
(d) Outline and discuss the pathology of benign and malignant breast lesions, neoplasms of bone, soft tissue, skin and
childhood tumours
(e) Outline the underlying principles, modes of action, pharmacokinetics, pharmacodynamics and major side effects of specific
chemotherapeutic, biotherapeutic and other anti-neoplastic agents and evaluate their use in treating neoplastic disease
(f) Describe the pathology of common multi-system autoimmune diseases including rheumatoid disease and connective tissue
diseases and discuss extracellular pathology and the pathology associated with ageing.
(g) Outline the principles underlying tissue transplantation and the immunologic basis and pathologic features of rejection.
(h) Outline the mode of action, pharmacokinetics, pharmacodynamics, principal side effects and major applications of the
immunosuppressive agents.
(i) Outline the mode of action, pharmacokinetics, pharmacodynamics, principal side effects and major applications of the anti-
inflammatory agents.

2. Improved their clinical and investigative skills by being able to:
(a) Formulate an approach to the differential diagnosis, prognostic evaluation and management of neoplastic disease and
outline and discuss the medical issues for the care of the cancer patient.
(b) Formulate an approach to the diagnosis, laboratory investigation and treatment of autoimmune and multisystem diseases
and transplant rejection.

3. Improved their professional and personal skills by:
(a) Observing and assimilating the professional attitudes of the oncologist, clinical pharmacologist, immunologist and
pathologist as they provide clinical illustrations of disease.
(b) Appreciating the integral importance of Multidisciplinary Team (MDT) approaches to the delivery of personalised patient
care.

Student Effort Hours:
Student Effort Type Hours
Specified Learning Activities

8
Autonomous Student Learning

56
Lectures

25
Tutorial

2
Seminar (or Webinar)

2
Conversation Class

3
Computer Aided Lab

1
Online Learning

5
Project Supervision

2
Total

104

Approaches to Teaching and Learning:
This module contains:

Lectures
Tutorials
CAL lab
Clinical Seminar
BMJ tutorials (online)

Requirements, Exclusions and Recommendations
Learning Requirements:

Students are required to have a background in human physiology and biochemistry

AND to have studied the Medical Microbiology, Medical Genetics and Neoplasia Module (MDSA20240) AND Biochemistry, Immunology & Pharmacology (PATH20000)

Specifically, students are required to have studied modules covering cellular and tissue responses to injury, cell death, inflammation, and human immunology.

Learning Exclusions:

PHAR 30100

Learning Recommendations:

Students wishing to register for this module as an Elective must please contact the Module Coordinator.


Module Requisites and Incompatibles
Required:
MDSA20240 - Micro, Med Genet, Neoplasia, PATH20000 - Biochem,Immunol&Pharmacol

Incompatibles:
PHAR30010 - Chemotherapeutic agents

Additional Information:
Students must have taken MDSA20240 AND PATH20000 in order to register to this module.

Equivalents:
Oncology & Immunopathology (PATH30190)


 

Assessment Strategy
Description Timing Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Exam (In-person): 30 min CAL lab prescribing assessment Week 14 Standard conversion grade scale 40% No
20
 No
Group Work Assignment: Multidisciplinary Team (MDT) group assignment. This will be subject to academic and peerScholar assessment. Week 9 Graded No
25
 No
Exam (In-person): SAQ component of 2 hour written exam End of trimester
Duration:
2 hr(s)
 Standard conversion grade scale 40% No
30
 No
Exam (In-person): MCQ component of 2 hour written exam End of trimester
Duration:
2 hr(s)
 Standard conversion grade scale 40% No
20
 No
Quizzes/Short Exercises: Submission of 5 X Certificates of Completion of online British Medical Journal (BMJ) tutorials in selected thematic areas Week 12 Graded No
5
 No

Carry forward of passed components
No
 

Resit In Terminal Exam
Summer Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 

Feedback Strategy/Strategies

• Group/class feedback, post-assessment

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Assoc Professor Helen Gallagher Lecturer / Co-Lecturer
Dr Melinda Halasz Lecturer / Co-Lecturer
Dr Jan Iglesias Lecturer / Co-Lecturer
Jan Iglesias Lecturer / Co-Lecturer
Professor Amanda McCann Lecturer / Co-Lecturer
Dr Sami Termanini Lecturer / Co-Lecturer
Dr Eleanor Wallace Lecturer / Co-Lecturer

Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
Spring Lecture Offering 1 Week(s) - 25, 26 Fri 09:00 - 09:50
Spring Lecture Offering 1 Week(s) - 23 Fri 10:00 - 10:50
Spring Workshop Offering 1 Week(s) - 33 Fri 10:00 - 10:50
Spring Lecture Offering 1 Week(s) - 22 Fri 16:00 - 16:50
Spring Workshop Offering 1 Week(s) - 20 Mon 12:00 - 12:50
Spring Lecture Offering 1 Week(s) - 21, 23, 24, 25, 26, 30 Mon 12:00 - 12:50
Spring Lecture Offering 1 Week(s) - 32 Mon 12:00 - 12:50
Spring Lecture Offering 1 Week(s) - 24, 25 Mon 17:00 - 17:50
Spring Lecture Offering 1 Week(s) - 32 Mon 17:00 - 17:50
Spring Lecture Offering 1 Week(s) - 24 Thurs 08:00 - 08:50
Spring Lecture Offering 1 Week(s) - 30 Thurs 11:00 - 11:50
Spring Lecture Offering 1 Week(s) - 31 Thurs 11:00 - 11:50
Spring Computer Aided Lab Offering 1 Week(s) - 32 Thurs 11:00 - 11:50
Spring Computer Aided Lab Offering 1 Week(s) - 33 Thurs 11:00 - 11:50
Spring Lecture Offering 1 Week(s) - 24 Tues 08:00 - 08:50
Spring Lecture Offering 1 Week(s) - 25, 26 Tues 10:00 - 10:50
Spring Lecture Offering 1 Week(s) - 22 Tues 11:00 - 11:50
Spring Lecture Offering 1 Week(s) - 30 Tues 11:00 - 11:50
Spring Workshop Offering 1 Week(s) - 32 Tues 11:00 - 12:50
Spring Lecture Offering 1 Week(s) - 23 Tues 12:00 - 12:50
Spring Lecture Offering 1 Week(s) - 33 Tues 12:00 - 12:50
Spring Lecture Offering 1 Week(s) - 20 Tues 13:00 - 13:50
Spring Lecture Offering 1 Week(s) - 21 Tues 14:00 - 14:50
Spring External & School Exams Offering 1 Week(s) - 30 Tues 15:00 - 18:50
Spring Lecture Offering 1 Week(s) - 30, 31 Wed 11:00 - 11:50
Spring Lecture Offering 1 Week(s) - 30 Wed 14:00 - 14:50
Spring External & School Exams Offering 1 Week(s) - 30 Wed 15:00 - 18:50
Spring Tutorial Offering 1 Week(s) - 31 Mon 16:00 - 16:50
Spring Tutorial Offering 1 Week(s) - 33 Wed 13:00 - 13:50
Spring Tutorial Offering 2 Week(s) - 31 Mon 16:00 - 16:50
Spring Tutorial Offering 2 Week(s) - 33 Wed 13:00 - 13:50
Spring Tutorial Offering 3 Week(s) - 31 Mon 16:00 - 16:50
Spring Tutorial Offering 3 Week(s) - 33 Wed 13:00 - 13:50
Spring Tutorial Offering 4 Week(s) - 31 Mon 17:00 - 17:50
Spring Tutorial Offering 4 Week(s) - 33 Wed 13:00 - 13:50
Spring Tutorial Offering 5 Week(s) - 31 Mon 17:00 - 17:50
Spring Tutorial Offering 5 Week(s) - 33 Wed 14:00 - 14:50
Spring Tutorial Offering 6 Week(s) - 31 Mon 17:00 - 17:50
Spring Tutorial Offering 6 Week(s) - 33 Wed 14:00 - 14:50
Spring Tutorial Offering 7 Week(s) - 31 Mon 17:00 - 17:50
Spring Tutorial Offering 7 Week(s) - 33 Wed 14:00 - 14:50
Spring Tutorial Offering 8 Week(s) - 32 Fri 14:00 - 14:50
Spring Tutorial Offering 8 Week(s) - 33 Thurs 14:00 - 14:50
Spring Tutorial Offering 9 Week(s) - 32 Fri 13:00 - 13:50
Spring Tutorial Offering 9 Week(s) - 33 Thurs 14:00 - 14:50
Spring Tutorial Offering 10 Week(s) - 32 Fri 13:00 - 13:50
Spring Tutorial Offering 10 Week(s) - 33 Thurs 15:00 - 15:50
Spring Tutorial Offering 11 Week(s) - 32 Fri 13:00 - 13:50
Spring Tutorial Offering 11 Week(s) - 33 Thurs 15:00 - 15:50
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