PATH20000 Biochem,Immunol&Pharmacol

Academic Year 2022/2023

This module forms part of the core curriculum for the Graduate Entry into Medicine (GEM) Programme. The course consists of material covering 5 main themes; 1) Macromolecules of Life, 2) Cellular Metabolism 3) Cellular Adaptation, Injury and Death, 4) The Immune System in Health and Disease and 5) Principles of Pharmacology.

A basic understanding of protein structure and function, metabolism, gene expression, pathology, immunology and inflammation will be integrated into specific examples of disease progression. This module will also introduce the student to basic pharmacological principles including molecular pharmacology, kinetics of drug metabolism and action, and the identification of key targets amenable to pharmacological intervention.

Show/hide contentOpenClose All

Curricular information is subject to change

Learning Outcomes:

Under each of the 5 themes, on completion of this module you will be able to:

1. Macromolecules of Life
 Detail the structure and function of proteins, nucleic acids, carbohydrates and lipids.

2. Cellular Metabolism
 Describe the biochemical basis for energy generation within the cell and detail the chemical processes underpinning the synthesis and metabolism of carbohydrates, lipids, amino acids, nucleotides and porphyrin.

3. Cellular Adaptation Injury and Death
 Outline the range of adaptive cellular responses in the body occurring secondary to stress, increased or decreased workload.
 Describe the main morphological features and intracellular signalling cascades associated with necrotic and apoptotic cell death.

4. The Immune System in Health and Disease
 Describe structure and function of the innate and adaptive arms of the immune response
 Synthesise the involvement of the innate and adaptive immune response in responses to infection and the induction of immunopathology.

5. Principles ofPharmacology:-
 Describe the basic principles that determine absorption, distribution, metabolism and excretion of drugs.
 Predict the time course of drug concentrations in the body, and formulate therapeutic dosage regimes.
 Explain the principles of drug-receptor interactions, understand the concepts of receptors and signal transduction systems and describe the basis on which receptor subtypes are distinguished.

Indicative Module Content:

The module provides a broad overview of:
The macromolecules of life - proteins, nucleic acids, carbohydrates and lipids.
Cellular metabolism of carbohydrates, lipids, amino acids, nucleotides and porphyrins.
Adaptive cellular responses leading to activation of cell death
Cellular composition of the immune system and its function in health and disease
Principles of pharmacology that determine absorption, distribution, metabolism and excretion of drugs and their mode of action

Student Effort Hours: 
Student Effort Type Hours
Lectures

45

Tutorial

5

Autonomous Student Learning

100

Total

150

Approaches to Teaching and Learning:
The key teaching and learning on the module is achieved by a series of face-to-face lectures; given the diverse academic background of the class, peer support is encouraged. Interactive group tutorials based on clinical vignettes are used to support learning. As and when required class revision sessions are used to address shortcomings in the assimilation of the information provided in lectures. Additional basic tutorial sessions will be offered which we strongly encourage students with no science background to attend. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Continuous Assessment: One short answer question (SAQ) (600 word limit) to be submitted mid-term. Varies over the Trimester n/a Graded No

15

Examination: Exit exam consists of a mix of multiple choice questions and short answer questions
2 hour End of Trimester Exam No Graded No

85


Carry forward of passed components
No
 
Resit In Terminal Exam
Spring Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
• Peer review activities

How will my Feedback be Delivered?

Exemplars of continuous assessments will be provided to students upon completion of their assessment. Exemplars from previous years are also available prior to assessment submission in Brightspace. Students can request feedback upon receipt of final grade. Peer Scholar will be utilized prior to submission of continuous assessments whereby students can receive feedback from each other and make appropriate changes prior to assignment deadline.

Name Role
Dr Paul Crossey Lecturer / Co-Lecturer
Professor Catherine Godson Lecturer / Co-Lecturer
Dr Peter Holloway Lecturer / Co-Lecturer
Dr Stephen Lalor Lecturer / Co-Lecturer
Professor Stephen Pennington Lecturer / Co-Lecturer
Professor Cormac Taylor Lecturer / Co-Lecturer
Assoc Professor Paula Byrne Tutor
Dr Fiona McGillicuddy Tutor
Professor Bill Watson Tutor