MEEN40630 Biomaterials

Academic Year 2023/2024

At the end of this module, it is anticipated that students will have obtained a detailed understanding the major classes of biomaterials (e.g. metals / alloys, ceramics / glasses, natural / synthetic / stimuli responsive polymers and composites thereof) and cell-derived devices used in medical device, pharmaceutical, tissue engineering and regenerative medicine sectors. It is also expected that the students will have obtained a detailed understanding of different biomaterial fabrication and characterisation methods, specific to a cell type and/or clinical indication. It is also expected that the students will have obtained a detailed understanding of biocompatibility, host response and implant failure mechanisms, as well as ethical considerations related to medical device development.

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Curricular information is subject to change

Learning Outcomes:

Upon completion of the module, the student will be able to:
- Describe the use of the major classes of biomaterials (e.g. metals / alloys, ceramics / glasses, natural / synthetic / stimuli responsive polymers and composites thereof) in medical device, pharmaceutical, tissue engineering and regenerative medicine sectors.
- Describe the use of cell-derived biomaterials in medical device, pharmaceutical, tissue engineering and regenerative medicine sectors.
- Select appropriate biomaterial(s) and processing method(s) for the development of devices for a specific cell type and/or clinical indication.
- Specify biophysical, biochemical and biological in vitro microenvironment modulators that control cell fate.
- Specify suitable methods for biophysical, biochemical and biological characterisation of implantable medical devices for a specific clinical indication.
- Understand mechanisms involved in implant failure.
- Understand cytotoxicity and biocompatibility issues relating to implantable medical devices.
- Appreciate regulatory requirements in the development of medical devices.
- Appreciate important ethical considerations in different areas of medical device development.
- Appreciate innovation, commercialisation and clinical translation in medical device development.
- Report and disseminate scientific findings.

Indicative Module Content:

- Definitions of biomaterials, biocompatibility, advanced therapy medicinal products, personalised medicine, etc.
- Introduction to different classes of biomaterials (ceramics / glasses, metals / alloys, natural / synthetic / stimuli responsive polymers)
- Introduction to bottom-up / top-down nano- and micro- biomaterial processing methods for the development of 2D and 3D devices (e.g. sponges, hydrogels, imprinted substrates, electrospun scaffolds, etc.)
- Introduction to biomaterials characterisation as necessary (e.g. structural, thermal, mechanical, biological properties, including preclinical and clinical assessment)
- Discuss implant failure
- Introduction to cellular systems and discussion on how we can control cell fate
- Introduction to commercialisation, clinical translation and regulatory requirements
- Discussions on ethical issues associated with biomaterials development
- Clinical indications as necessary (e.g. bone, cartilage, tendon, skin, cornea, etc.)
- Industry talk(s)
- Intellectual property management

Student Effort Hours: 
Student Effort Type Hours
Specified Learning Activities

4

Autonomous Student Learning

100

Lectures

23

Seminar (or Webinar)

4

Total

131

Approaches to Teaching and Learning:
The content is delivered via lectures, case studies and invited talks. The assessment is based on in class multiple choice question exams, individual short assignments and an in class written exam. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Equivalents:
Biomaterials (EEME40490)


 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Assignment: Short assignments associated with invited seminars Throughout the Trimester n/a Graded No

10

No
Examination: In class written exam Unspecified No Graded No

50

No
Multiple Choice Questionnaire: In class multiple choice question exam I Unspecified n/a Graded No

20

No
Multiple Choice Questionnaire: In class multiple choice question exam II Unspecified n/a Graded No

20

No

Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring Yes - 1 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
• Online automated feedback
• Peer review activities
• Self-assessment activities

How will my Feedback be Delivered?

Letter grades and brief comments related to the two written assignments will be provided to students within three weeks of submission deadlines.