Learning Outcomes:
On successful completion of this module the student will be able to:
1. Demonstrate a knowledge and understanding of key concepts in fluid mechanics as applied to the cardiovascular system
2. Identify, analyse and solve technical problems using the conservation equations of mass, momentum and energy
3. Understand the physiology and functionality of the heart
4. Distinguish the main differences between the arterial and venous blood flow
5. Analyse and solve technical problems relating to blood flow in the arterial system
6. Understand the concept of a windkessel model and solve numerically related problems using Matlab
7. Plan and conduct experiments involving the application of computational fluid dynamics to cardiovascular flows
Indicative Module Content:
REVIEW OF BASIS FLUID MECHANICS
Continuum; stress and pressure; kinematics; viscosity; buoyancy; control volume analysis; Navier-Stokes equations; Bernoulli equation
MACROCIRCULATION
The Heart: cardiac physiology; electrocardiogram; cardiac cycle; heart valve function; coronary artery disease, myocardial infarction, heart valve disease
Arterial and Venous Flow: arterial system physiology; venous system physiology; blood cells, plasma and rheology; pressure, resistance and flow; Windkessel model; Wave propagation; Flow separation at bifurcations; pulsatile flow and turbulence; atherosclerosis, stoke, blood pressure, platelet activation, thromboembolism and aneurysm
SPECIALITY CIRCULATIONS
Flow in the Lungs: physiology; elasticity of lung blood vessels and alveoli; pressure-volume relationship for air flow; Emphysema, asthma and tuberculosis
MODELING AND EXPERIMENTAL TECHNIQUES
In Silico Biofluid Mechanics: computational fluid dynamics; fluid structure interaction; dynamics similarity
In Vitro Biofluid Mechanics: particle image velocimetry; laser Doppler velocimetry; flow chambers
In Vivo Biofluid Mechanics: Doppler ultrasound; phase transport magnetic resonance imaging; Other techniques