MDCS42220 High Throughput technologies

Academic Year 2020/2021

Rapid technological advances have made high-throughput technologies available for the study of biological systems, laying the foundation for the development of the “-omics” era. This offers the ability to carry out high-throughput studies characterized by big data production. Indeed, the completion of the first human genome sequence and the availability of high-scale technological tools have made it possible to study genomics, transcriptomics, epigenomics, and other -omic sciences at a previously unthinkable level. The integration of these disciplines is further increasing our understanding of the molecular bases of human diseases. This module aims to offer a comprehensive overview of the fundamentals of omic sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to:
1) Explain fundamental principles of genome, epigenome, transcriptome, proteome and metabolome biology.
2) Describe the various high-throughput technologies available to investigate biological systems in health and disease.
3) Outline the advantages/limitations of different omics approaches, and key factors underlying choice of biological material for studies.

Indicative Module Content:

This module aims to offer a comprehensive overview of the fundamentals of omics sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases. Topics covered include introductory lectures to explore fundamental principles of the human genome, transcriptome, epigenome, proteome and metabolome. Applications/Technology lectures will cover practical consideration in biological sample sourcing, best practices, sample preparation, technological solutions and interpretation. Content will be delivered by UCD School of Medicine staff as well as invited expert lecturers with pharma experience.

On completion of this module students should be able to:
1) Explain fundamental principles of genome, epigenome, transcriptome, proteome and metabolome biology.
2) Describe the various high-throughput technologies available to investigate biological systems in health and disease.
3) Outline the advantages/limitations of different omics approaches, and key factors underlying choice of biological material for studies.

Student Effort Hours: 
Student Effort Type Hours
Autonomous Student Learning

122

Lectures

18

Tutorial

6

Seminar (or Webinar)

4

Total

150

Approaches to Teaching and Learning:
Lectures.
Viewing of videos explaining key scientific and technical concepts.
Online MCQ assessments delivered using Brightspace.
In-class problem-solving exercises.
Self-directed learning using materials provided on Brightspace.
Student presentations. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Group Project: Poster Assignment Unspecified n/a Graded No

15

Project: PROJECT WORK: ASSIGNMENT CENTRED ON THE ROLE OF HIGH THROUGHPUT TECHNOLOGIES IN UNDERSTANDING/DIAGNOSING/MANAGING A GIVEN DISEASE Unspecified n/a Graded No

15

Examination: 2 hour examination 2 hour End of Trimester Exam No Graded No

70


Carry forward of passed components
No
 
Resit In Terminal Exam
Summer Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment

How will my Feedback be Delivered?

Class performance in assessment will be discussed in a general feedback discussion of clear trends and examples without addressing individual performance. Individuals requesting one to one feedback will schedule appointments with the MC or lecturer at mutually agreeable times.

Name Role
Professor Walter Kolch Lecturer / Co-Lecturer
Professor Brendan Loftus Lecturer / Co-Lecturer
Dr Vadim Zhernovkov Lecturer / Co-Lecturer