GEOL20240 Medical Geology

Academic Year 2023/2024

This module explores the linkages between human health and the geosphere. Medical Geology is a new and rapidly evolving field within the geosciences. This module explores the complex relationships between human health and disease, focusing on those aspects of the surface and near-surface environment that reflect underlying geological controls. Topics include health-relevant soil and water geochemistry, food-soil-rock connections, the role of soil and rock type in determining local to regional scale excesses and deficiencies in essential and trace elements, geochemical controls on metal speciation and bioavailability, natural processes that influence atmospheric dust and other particulate loads (e.g. desert dusts, volcanic emissions, naturally occurring carcinogenic minerals such as some asbestos-group minerals, nanominerals), naturally occurring radioactivity (e.g. uranium, radon), synergistic inter-actions between multiple geogenic pollutants (e.g lead, arsenic and uranium) in groundwater and implications for human health, biomineralisation processes, geophagy, the interactions between minerals and microbes including current research on the antimicrobial properties of certain minerals, the use of techniques with roots in geochemistry (e.g. heavy stable isotopes) in medical science.

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Curricular information is subject to change

Learning Outcomes:

The learning outcomes of this elective module are to provide undergraduate students who have an interest in Health Science and Medicine with: (i) an improved knowledge of how naturally occurring Earth materials (e.g. carcinogenic minerals, geogenic contaminants in groundwater, bedrocks and soils) can impact on human health and disease, (ii) a better appreciation of the complex pathways through which humans can be exposed to both excesses and deficiencies of essential and trace elements via multiple processes involving the food-soil-rock nexus and water-rock interactions, (iii) the variety of potential exposure pathways including direct and indirect ingestion of geological contaminants, inhalation of airborne dusts and harmful but naturally occurring gases (e.g. radon), (iv) an understanding of how the speciation and therefore the bioavailability of certain heavy metals varies in a range of geological and geochemical environments and finally (v) how methods that were originally developed in the field of geochemistry (e.g. Fe and Cu heavy metal isotope geochemistry) are finding novel applications in the diagnosis of certain pathologies.

Indicative Module Content:

Section 1: Introduction to Medical Geology, Minerals and Health
Lecture 1 (FMcD)
PART 1: Brief definition/discussion of the scope of Medical Geology as a field. Definitions of minerals (geological) and meaning sensu-lato.
PART 2: Major, essential and trace elements for the human body. Toxicity effects of selected elements.
PART 3: The food-soil-rock connection – deficiencies and excesses.

Lecture 2 (FMcD)
High level general introduction to exposure pathways for humans
PART 1: Exposure via drinking water.
PART 2: Exposure via soils, food crops and seafood.
PART 3: Exposure via direct inhalation and ingestion of soils and dusts.

Lecture 3 (FMcD)
Specific biological and health functions of the essential elements such as Ca, Mg, K, Fe, Cr, Co, Cu, I, P, S, Se, Zn, Mo, F, Si.
PART 1: The major elements (O, C, H, N)
PART 2: The minor elements (Ca, P, Mg, Na, K, S, Cl)
PART 3: The essential trace elements (F, Si, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Mo, I, W)

Lecture 4 (FMcD): Specific biological and health functions – detailed case studies.
PART 1: Selenium
PART2: Cobalt
PART 3: Iodine (Goitre)



Section 2: Ingestion Pathways; Water and Food

Lecture 5 (FMcD)
Common geogenic and anthropogenic contaminants. Effects of exposure to toxic levels of some trace elements such as arsenic, uranium, chromium, cadmium, lead. Health implications of nitrate pollution in groundwater. WHO guidelines, baseline thresholds and multivariate compositional analysis to discern synergistic effects between contaminants.
PART 1: Arsenic and Chromium
PART2: Cadmium and Lead
PART 3: Nitrates and other nitrogenous compounds

Lecture 6 (FMcD)
Bioavailability and uptake of elements. Some general information on factors affecting bioavailability. Organometallic forms. Methylation and other bio-transformations that influence metal speciation, bioavailability and uptake by organisms with a focus on Hg and As. Bioaccumulation and biomagnification effects with particular reference to fish- and shellfish-rich diets. Emerging contaminants in groundwater and their biogeochemistry.
PART 1: Mercury – organometallic forms including methyl Hg
PART2: Role of organics in lead bioavailability and toxicity
PART 3: Role of organics in arsenic bioavailability and toxicity

Lecture 7 (FMcD)
‘Mineral’ deficiencies. Geological impacts on nutrition with a focus on the impact of rocks and soils on soil water chemistry and therefore uptake by plants/animals/food. Effects of deficiencies of certain elements such as iodine, calcium, magnesium, potassium, sodium, iron, zinc, copper, fluorine and selenium and how these are transmitted to humans. Health effects of lithium in groundwater.
PART 1: The chemistry of rocks, soils and soil solutions
PART2: Role of soil pH and carbonates in causing deficiencies
PART 3: Role of soil organics in causing deficiencies

Lecture 8 (FMcD)
‘Mineral’ excesses. Geological impacts on nutrition with a focus on the impact of rocks and soils. Links to geology and soil geochemistry. Soil solutions. Health effects of lithium in groundwater. Effects of excesses of certain elements such as iodine, calcium, magnesium, potassium, sodium, iron, zinc, copper, fluorine and selenium in soils and soil solutions and how these are transmitted to humans.


Section 3: Inhalation pathways, airborne minerals and other particulates
Lectures 9 and 10 (JFM): Mineral types (brief introduction), sizes, shapes and typical specific surface areas. Size range of atmospheric particulates from different sources. Naturally occurring mineral dust sources (e.g. desert dusts, soil erosion, wildfires and volcanoes). Mechanics of mineral dust inhalation, nanominerals and other nanoparticles in the human respiratory system. Volcanic gases.
Lectures 11 and 12 (JFM) : Anthropogenic dust sources. Quarrying and mining. Asbestos and other fibrous mineral dusts, erionite, silicosis, black lung, airborne heavy metals (e.g. Pb, As) around some extractive and other industries (e.g. glass), airborne nanoparticles. Effect of hydrocarbon extraction, especially fracking on mobilisation of geogenic contaminants.


Section 4: Radioactivity and radioactive minerals
Lecture 13 (JFM): Radon. Sources and pathways into buildings. Health effects and links to smoking. Other naturally occurring radioactive elements and their biological/medical effects such as uranium, thorium, radium etc.
Lectures 14 (JFM): Artificially produced radioisotopes from nuclear facilities. The ‘bomb spike’ in 14C. Health impacts of depleted uranium (DU) from munitions. Fallout from nuclear accidents such as Chernobyl and Fuchishima. Occurrence and biological uptake behaviour of radioactive strontium, caesium, plutonium, americium etc. Particle reactivity and plutonium in Irish Sea.


Section 5: Biomineralization in the human body as affected and inspired by Earth materials (FMcD)
Lecture 15 (FMcD): Pathological and other detrimental biomineralization effects in the human body (e.g. plaque, kidney and gall stones, gout etc). Health effects of water hardness. Effect of water hardness on coronary health.
Lecture 16 (FMcD): Mineralisation of bones and teeth. Intentional addition of some elements to water sources to influence biomineralisation (e.g. fluoridation of drinking water). Fluorosis. Synergistic interactions between elements (e.g. F in bone building). Bioengineered and bioactive glass and mineral-inspired scaffolds for bone regeneration and reconstruction.


Section 6: Geochemistry and Minerals in medicine (FMcD and JFM)
Lecture 17 (FMcD): History of geophagy. Effects of unintended ingestion of minerals by children. Use of industrial minerals in pharmaceutical and skin cosmetic formulations. Soil minerals as vectors for pathogens.
Lecture 18 (FMcD): Microbes and minerals. Mineral selection of microbial populations in nature. Current research on the antimicrobial properties of minerals.
Lecture 19 (JFM): Use of geochemistry tools (e.g. stable isotopes of Fe and Cu) in medical research and in understanding hemochromatosis and cancer progression.

Student Effort Hours: 
Student Effort Type Hours
Specified Learning Activities

12

Autonomous Student Learning

50

Online Learning

38

Total

100

Approaches to Teaching and Learning:
This is an online module. Material that is delivered online will be supplemented by five online learning exercises that are designed to: (i) complement and deepen learning and (ii) provide feedback to students. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Multiple Choice Questionnaire (Short): End of Semester MCQ Exam 1 hour End of Trimester Exam n/a Standard conversion grade scale 40% No

60

No
Multiple Choice Questionnaire (Short): Mid-term MCQ (40 minute) Week 5 n/a Standard conversion grade scale 40% No

40

No

Carry forward of passed components
Yes
 
Remediation Type Remediation Timing
Repeat Within Two Trimesters
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Group/class feedback, post-assessment
• Online automated feedback

How will my Feedback be Delivered?

Online feedback is given via several student quiz exercises in Brightspace Group feedback via Brightspace after mid-term MCQ

Name Role
Assoc Professor Julian Menuge Lecturer / Co-Lecturer