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CLIP40010

Academic Year 2024/2025

High Throughput Technologies (CLIP40010)

Subject:
Clinical Pharmacology
College:
Health & Agricultural Sciences
School:
Medicine
Level:
4 (Masters)
Credits:
5
Module Coordinator:
Dr Eoin Brennan
Trimester:
Autumn
Mode of Delivery:
Blended
Internship Module:
No
How will I be graded?
Letter grades

Curricular information is subject to change.

High-throughput technologies (HTTs) have become crucial to medical research areas, including drug discovery, genomics, and molecular biology.These technologies allow scientists and clinicians to carry out studies that are expected to transform medicine, and ultimately develop new medicines and therapeutic management strategies tailored to individual patients. This offers the ability to carry out high-throughput studies characterized by big data production. Indeed, the completion of the first human genome sequence and the availability of high-scale technological tools have made it possible to study genomics, transcriptomics, epigenomics, and other -omic sciences at a previously unthinkable level. The integration of these disciplines is further increasing our understanding of the molecular bases of human diseases. This module aims to offer a comprehensive overview of the fundamentals of omic sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases. Students will learn from academic and industry experts on the fundamentals and applications of HTTs to address global health problems. Delivery of material is flexible and includes in-class and online sessions, laboratory demonstrations of HTTs by the experts, as well as group work presentations to learn more about the latest advances in HTTs.

About this Module

Learning Outcomes:

On completion of this module students should be able to:
1) Explain fundamental principles of genome, epigenome, transcriptome, proteome and metabolome biology.
2) Describe the various high-throughput technologies available to investigate biological systems in health and disease.
3) Outline the advantages/limitations of different omics approaches, and key factors underlying choice of biological material for studies.

Indicative Module Content:

This module aims to offer a comprehensive overview of the fundamentals of omics sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases. Topics covered include introductory lectures to explore fundamental principles of the human genome, transcriptome, epigenome, proteome and metabolome. Applications/Technology lectures will cover practical consideration in biological sample sourcing, best practices, sample preparation, technological solutions and interpretation. Content will be delivered by UCD School of Medicine staff as well as invited expert lecturers with pharma experience.

Student Effort Hours:
Student Effort Type Hours
Autonomous Student Learning

122
Lectures

13
Tutorial

4
Laboratories

4
Total

143

Approaches to Teaching and Learning:
Lectures.
Viewing of videos explaining key scientific and technical concepts.
Online MCQ assessments delivered using Brightspace.
Self-directed learning using materials provided on Brightspace.
Student presentations and critical analysis of research papers.
Laboratory tours and demonstrations.

Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Equivalents:
High Throughput Technologies (PATH40080)


 

Assessment Strategy
Description Timing Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Group Work Assignment: Working in groups you will be tasked with discussing a topical paper in the area of precision medicine/technology applications. Week 5, Week 9 Graded No
30
 No
Exam (In-person): 1 hour examination (mix of multiple choice and short answer questions) End of trimester
Duration:
1 hr(s)
 Standard conversion grade scale 40% No
50
 No
Group Work Assignment: Groupwork journal club/presentation Week 11, Week 12 Graded No
20
 No

Carry forward of passed components
No
 

Resit In Terminal Exam
Spring Yes - 1 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 

Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
• Peer review activities

How will my Feedback be Delivered?

Individuals requesting one to one feedback can schedule appointments with the MC or lecturer at mutually agreeable times. Feedback on essays and group work will be provided prior to submission.

Name Role
Professor Lorraine Brennan Lecturer / Co-Lecturer
Assoc Professor Helen Gallagher Lecturer / Co-Lecturer
Professor Brendan Loftus Lecturer / Co-Lecturer
Professor Denis Shields Lecturer / Co-Lecturer
Professor Matthias Wilm Lecturer / Co-Lecturer

Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
Autumn Lecture Offering 1 Week(s) - 1, 2, 3, 4, 5, 6, 7 Wed 10:00 - 11:50
Autumn Lecture Offering 1 Week(s) - 12 Wed 10:00 - 11:50
Autumn Lecture Offering 1 Week(s) - 8, 9, 10, 11 Wed 10:00 - 11:50
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