CHEN40860 Gene Ther & Vacc Tech & Proc

Academic Year 2023/2024

Gene therapies have the potential to treat and even cure disease ranging from blood disorders to ophthalmic diseases and cancer. The objective of this module is to provide students with an understanding of the concepts and technologies underpinning the production of gene therapies and modern vaccines. This module will cover both viral and non-viral gene therapy and vaccine manufacturing approaches. Viral vectors including Adeno-associated virus, adenovirus and lentivirus will be addressed, with a focus on the main production platforms currently used, strategies for vector purification and subsequent analytical techniques for quality, purity and efficacy. The production of non-viral gene therapies (mRNA, RNAi, tRNA, circRNA), novel vaccines (nucleic acid, AAV, Ad) and the associated delivery technologies will also be addressed.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to:
1. Understand the basis of getting nucleic acid into cells and for using viruses as vectors for gene delivery and as vaccines
2. Describe the main viral vectors in clinical use and the methods by which they are produced industrially
3. Understand how gene therapies can be used in vivo and ex vivo to modify patient cells including using gene editing tools
4. Discuss the different analytical challenges and technologies associated with viral gene therapy characterisation
5. Understand the mode-of-action of different non-viral gene therapies and RNA-based vaccines
6. Describe the manufacturing processes involved in non-viral therapies and associated analytics

Student Effort Hours: 
Student Effort Type Hours
Lectures

16

Autonomous Student Learning

104

Total

120

Approaches to Teaching and Learning:
Lectures 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Multiple Choice Questionnaire: MCQ throughout semester
Grading will be non-standard linear scale:
%
A+ ≥95 100
A ≥90 <95
A- ≥85 <90
B+ ≥80 <85
B ≥75 <80
B- ≥70 <75
C+ ≥65 <70....etc
Throughout the Trimester n/a Alternative linear conversion grade scale 40% No

100


Carry forward of passed components
Yes
 
Remediation Type Remediation Timing
In-Module Resit Prior to relevant Programme Exam Board
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Online automated feedback

How will my Feedback be Delivered?

Not yet recorded.

Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
 
Spring
     
Lecture Offering 1 Week(s) - 21, 23, 26, 28 Fri 14:00 - 17:50