Learning Outcomes:
On completion of this module students should be able to:
1. Provide an overview of cell-based therapies and approved products
2. Show an understanding of the biology of different types of stem cells including MSC, ESC, iPS
3. Explain the differences between autologous and allogeneic therapies
4. Be able to describe CAR-T cell biology and functional properties
5. Provide information on the upstream processes involved in manufacture of cell therapies including media and bioreactor selection
6. Provide information on the downstream processes involved in the manufacture of cell therapies including harvest, concentration and cryopreservation
7. Understand the importance of monitoring and measuring critical quality attributes of cell therapies including cell viability, potency and function.
Case studies on specific topics e.g. Limbal stem cells, cardiovascular stem cells, CAR-T products, MSC preclinical and clinical trials
Indicative Module Content:
Overview of Advanced therapies
Products approved and in pipeline
Tyes of cell based therapies
Stem cells: MSC, ESc, iPSs
Isolation and purfication of stem cells
Media for stem cells
Stem cell growth in small and large-scale
Cell therapies: upstream processing
Cell therapies: downstream processing
Quality of cell therapies
Potency of cell therapies
Regulation of cell therapies
Case studies from commercial products
Cell therapy research topics