CHEN40850 Cell Therapy Tech & Processing

Academic Year 2023/2024

This module will provide an understanding of the technologies required for the development and delivery of cell therapy-based medicines. The fundamental scientific principles underpinning cell therapy products including cell sourcing, upstream and downstream processing for stem cells and CAR-T therapies will be presented. Case studies on specific topics related to stem cell biology and clinical applications will demonstrate the application of the principles outlined.

Show/hide contentOpenClose All

Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to:
1. Provide an overview of cell-based therapies and approved products
2. Show an understanding of the biology of different types of stem cells including MSC, ESC, iPS
3. Explain the differences between autologous and allogeneic therapies
4. Be able to describe CAR-T cell biology and functional properties
5. Provide information on the upstream processes involved in manufacture of cell therapies including media and bioreactor selection
6. Provide information on the downstream processes involved in the manufacture of cell therapies including harvest, concentration and cryopreservation
7. Understand the importance of monitoring and measuring critical quality attributes of cell therapies including cell viability, potency and function.
Case studies on specific topics e.g. Limbal stem cells, cardiovascular stem cells, CAR-T products, MSC preclinical and clinical trials

Indicative Module Content:

Overview of Advanced therapies
Products approved and in pipeline
Tyes of cell based therapies
Stem cells: MSC, ESc, iPSs
Isolation and purfication of stem cells
Media for stem cells
Stem cell growth in small and large-scale
Cell therapies: upstream processing
Cell therapies: downstream processing
Quality of cell therapies
Potency of cell therapies
Regulation of cell therapies
Case studies from commercial products
Cell therapy research topics

Student Effort Hours: 
Student Effort Type Hours
Lectures

16
Total

16
Approaches to Teaching and Learning:
Lectures
Case studies
Invited expert speakers 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Continuous Assessment: Assignments Varies over the Trimester n/a Graded No

100

Carry forward of passed components
Yes
 
Resit In Terminal Exam
Summer No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Online automated feedback

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Dr Daniela Boehm Lecturer / Co-Lecturer
Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
 
Spring
      
Lecture Offering 1 Week(s) - 20, 24, 25, 31 Fri 14:00 - 17:50