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Curricular information is subject to change
On completion of this module students should be able to:
1. Describe the general layout of an industrial biopharmaceutical facility
2. To identify the utilities and equipment required for production of biopharmaceuticals.
3. Describe the cleaning-in-place (CIP) and steam-in-place (SIP) protocols for setting up a stainless-steel bioreactor.
4. Measure the growth and viability of CHO cells manually and using an automated cell counter.
5. Measure the rate of glucose and lactate metabolism in CHO cells in culture.
6. Understand the steps involved in downstream processing of biopharmaceuticals in particular ultrafiltration and centrifugation.
7. Understand the steps involved in packing a large-scale chromatography unit.
Students will complete 6 experiments in NIBRT
1. Facilities
2. Cell Culture
3. Bioreactor SIP
4. Packing a large-scale chromatography column
5. Ultrafiltration
6. Disc stack centrifuge
| Student Effort Type | Hours |
|---|---|
| Laboratories | 24 |
| Autonomous Student Learning | 96 |
| Total | 120 |
Student should have successfully completed CHEN40040 Animal Cell Culture Technology OR MICR40020 Micro and Animal Cell Products in Semester 1
| Description | Timing | Component Scale | % of Final Grade | ||
|---|---|---|---|---|---|
| Lab Report: Lab reports | Coursework (End of Trimester) | n/a | Graded | No | 50 |
| Examination: End of lab session MCQ | 1 hour End of Trimester Exam | No | Other | No | 50 |
| Resit In | Terminal Exam |
|---|---|
| Summer | No |
• Feedback individually to students, post-assessment
Not yet recorded.
| Name | Role |
|---|---|
| Professor Niall Barron | Lecturer / Co-Lecturer |
| Ms Nicola Fortune | Lecturer / Co-Lecturer |
| Melissa Hoare | Lecturer / Co-Lecturer |
| Assoc Professor Susan McDonnell | Lecturer / Co-Lecturer |