CHEN40090 Bioprocessing Laboratory

Academic Year 2022/2023

This module will provide student with an overview of the commercial production of biopharmaceuticals in a GMP facility. Students will also gain understanding of the processes involved in both upstream (cell culture and growth in bioreactor) and downstream (harvest to fill-finish) production of biopharmaceuticals.

A non-standard mark-to-grade conversion system is used in this module for grades of C- and above (i.e. C-: 50.00-54.99; C: 55.00-59.99; C+: 60.00-64.99; B-: 65.00-69.99; B: 70.00-74.99; B+: 75.00-79.99; A-: 80.00-84.99; A: 85.00-89.99; A+:90.00-100.00).

Show/hide contentOpenClose All

Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to:

1. Describe the general layout of an industrial biopharmaceutical facility
2. To identify the utilities and equipment required for production of biopharmaceuticals.
3. Describe the cleaning-in-place (CIP) and steam-in-place (SIP) protocols for setting up a stainless-steel bioreactor.
4. Measure the growth and viability of CHO cells manually and using an automated cell counter.
5. Measure the rate of glucose and lactate metabolism in CHO cells in culture.
6. Understand the steps involved in downstream processing of biopharmaceuticals in particular ultrafiltration and centrifugation.
7. Understand the steps involved in packing a large-scale chromatography unit.

Indicative Module Content:

Students will complete 6 experiments in NIBRT
1. Facilities
2. Cell Culture
3. Bioreactor SIP
4. Packing a large-scale chromatography column
5. Ultrafiltration
6. Disc stack centrifuge

Student Effort Hours: 
Student Effort Type Hours


Autonomous Student Learning




Approaches to Teaching and Learning:
Requirements, Exclusions and Recommendations
Learning Requirements:

Student should have successfully completed CHEN40040 Animal Cell Culture Technology OR MICR40020 Micro and Animal Cell Products in Semester 1

Module Requisites and Incompatibles

Additional Information:
CHEN40040 OR MICR40020 must be completed in Semester 1 before registering for this module

Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Lab Report: Lab reports Coursework (End of Trimester) n/a Graded No


Examination: End of lab session MCQ 1 hour End of Trimester Exam No Other No


Carry forward of passed components
Resit In Terminal Exam
Summer No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Professor Niall Barron Lecturer / Co-Lecturer
Ms Nicola Fortune Lecturer / Co-Lecturer
Melissa Hoare Lecturer / Co-Lecturer
Assoc Professor Susan McDonnell Lecturer / Co-Lecturer