CHEN30040 Commercial Pharmaceutical & Bioprocessing Technology

Academic Year 2023/2024

This module deals with scientific, engineering and professional elements of commercial Pharmaceutical and Bioprocessing technology. Students will become familiar with the steps involved in both pharmaceutical and biopharmaceutical production, with a focus on key downstream unit operations like UF/MF and chromatography provided. The commercial production of insulin and insulin analogues in yeast and recombinant and conjugate vaccines in bacteria will be examined in detail. An overview of the production of biologics in mammalian cells will also be provided. Students will obtain a good grounding in the principles of bioreactor selection, design, scale-up and optimisation and will develop their ability to apply principles of mass transfer, fluid flow and heat transfer to bioreactor design and operation. Through a short series of company presentations, students will become familiar with the importance of the Bio/Pharmaceutical sector to the Irish economy. Students will also be assisted in preparing to apply for Internship and Graduate positions within this sector.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able:
1. To describe the drug development process from discovery to commercialisation
2. To describe the key operations involved in primary recover and downstream processing of biopharmaceuticals and demonstrate an understanding of the principles involved in chromatography.
3. To describe the industrial production of insulin in yeast cells and vaccines in bacterial expression systems.
4. To apply the bioreactor design equations to the analysis of microbial fermentations and cell cultures
5. To have a good grounding in the principles of bioreactor selection, design, scale-up and optimisation
6. To apply principles of mass transfer, fluid flow and heat transfer to bioreactor design and operation
7. To identify key ethical and intellectual property issues in the development of a Bio/Pharmaceutical process and/or product.
8. To understand the role of Chemical & Bioprocess Engineers in the Bio/Pharmaceutical sector and to identify key players and products.
9. To prepare effectively to apply for relevant positions within this sector.

Indicative Module Content:

Student Effort Hours: 
Student Effort Type Hours
Lectures

36

Tutorial

12

Specified Learning Activities

26

Autonomous Student Learning

50

Total

124

Approaches to Teaching and Learning:
Lectures
Seminars
Case studies 
Requirements, Exclusions and Recommendations
Learning Recommendations:

Student enrolling for this module must have previously passed CHEN20060 (Transport Phenomena). It is also recommended that students should have taken either BIOC20020 (Machinery of Life) or CHEN20050 (Biotechnology for Engineers).


Module Requisites and Incompatibles
Pre-requisite:
CHEN20060 - Transport Phenomena


 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: End of semester exam 2 hour End of Trimester Exam No Graded No

60

Assignment: Term paper: Each student will be assigned a primary research paper that they must critically evaluate. Varies over the Trimester n/a Graded No

30

Seminar: There will be a weekly series of seminars given by professional engineers and students must write a short report on these sessions. Throughout the Trimester n/a Graded No

10


Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Professor Eoin Casey Lecturer / Co-Lecturer
Dr Sorcha Daly Lecturer / Co-Lecturer
Dr Philip Donnellan Lecturer / Co-Lecturer
Dr Ioscani Jimenez Del Val Lecturer / Co-Lecturer
Mr Jim McKiernan Lecturer / Co-Lecturer
Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
 
Autumn
     
Lecture Offering 1 Week(s) - 1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12 Mon 15:00 - 15:50
Tutorial Offering 1 Week(s) - 1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12 Mon 16:00 - 16:50
Lecture Offering 1 Week(s) - Autumn: All Weeks Tues 12:00 - 12:50
Lecture Offering 1 Week(s) - 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 Tues 14:00 - 14:50
Autumn