CHEM40310 Catalytic Asymmetric Synthesis

Academic Year 2022/2023

The module aims to give students an advanced course on an area of synthetic organic chemistry of current importance, namely asymmetric synthesis. The key learningobjectives of this module are:a) To understand the need for asymmetric synthesis and a comparison of the currentlyused approaches,(b) To be able to apply selected chiral reagents, chiral auxiliaries and chiral catalystsin the asymmetric synthesis of organic compounds,(c) To understand the three-dimensional transition states in each of the aboveapproaches and thus understand why a particular stereoisomer is formed.(d) To be able to apply this methodology as key steps in the total synthesis ofmolecules of biological interest.The type of asymmetric transformations which will be discussed include C-H, C-Cand C-O bond formations. The application of transition metal complexes and organocatalysis to these transformations will be a particular emphasis.

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Curricular information is subject to change

Learning Outcomes:

On successful completion of this module, students should:
- Have a knowledge and understanding of modern approaches to asymmetricsynthesis;
- Be familiar with applications of transition metal complexes and theimportance of recent advances in chiral ligands;
- Be familiar with recent advances in the development and use oforganocatalysts for asymmetric synthesis;
- Be able to apply these chirotechnologies as key steps in the preparation ofbiologically important molecules.

Course is Graded as Pass (60%) or Honours (76%)"

Student Effort Hours: 
Student Effort Type Hours


Specified Learning Activities


Autonomous Student Learning




Approaches to Teaching and Learning:
Lectures and assignments. Extensive reading of the current literature. 
Requirements, Exclusions and Recommendations

Not applicable to this module.

Module Requisites and Incompatibles
Not applicable to this module.
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Assignment: Based on Course Materials and Literature Review x3 Varies over the Trimester n/a Graded No


Carry forward of passed components
Resit In Terminal Exam
Autumn No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment

How will my Feedback be Delivered?

The assignments will be in the order (a) Guiry; (b) Gilheany and (c) Connon. Graded assignments will be returned to the students.

Name Role
Professor Declan Gilheany Lecturer / Co-Lecturer