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Curricular information is subject to change
The ability to apply a combination of Mass Spectrometry, Ultraviolet-Visible Spectroscopy, Infrared Spectroscopy and NMR Spectroscopy (1H and 13C) for structure elucidation.Indicative Module Content:
Due to the COVID-19 pandemic, the mode of delivery, assessment and content of the module may be subject to change.
Mass Spectrometry - instrumentation; ion production by EI or CI; molecular ion; isotopes; N rule; fragmentation, rearrangement; characteristic processes of different organic classes; applications.Ultraviolet-Visible Spectroscopy - instrumentation; Types of electronic transitions; Conjugation; selected examples. Infrared Spectroscopy - types of vibration; Characteristic vibrations of different functional groups; emphasis on C=O group; applications. NMR Spectroscopy - introduction; CW vs FT NMR; 1H NMR; chemical shift; spin-spin coupling; integration; protons on heteroatoms; magnetic equivalence; AMX, ABX, and ABC spin systems; spin decoupling-1H-1H connectivity ; 13C NMR; decoupling; chemical shifts e.g. aromatic compounds; 2D NMR - 1H-1H connectivity (COSY); 1H-13C connectivity (APT, DEPT); nuclear Overhauser effect; examples.Structure elucidation - strategy; combined use of NMR, IR, MS, and UV; selected problems.
Naming of heterocycles; synthesis of pyrroles, furans, thiophenes, imidazoles, oxazoles, pyridines; aromaticity and heteroaromaticity; p-deficient/excessive heterocycles; reactivity of five membered heterocycles; electrophilic substitution; Diels-Alder reactions of furan, pyrrole, thiophene; reactivity of pyridine and pyridine-N-oxide; nucelophilic substitution of pyridine; reactivity of imidazole; structure and reactivity of organolithium reagents; lithiated derivatives of pyrrole, furan thiophene, pyridine.
|Student Effort Type||Hours|
|Autonomous Student Learning||
Not applicable to this module.
|Description||Timing||Component Scale||% of Final Grade|
|Examination: Written examination||2 hour End of Trimester Exam||Yes||Graded||No||
|Continuous Assessment: various assessments over the semester||Varies over the Trimester||n/a||Graded||No||
|Lab Report: Laboratory, continuous assessment.||Varies over the Trimester||n/a||Graded||No||
|Resit In||Terminal Exam|
|Spring||Yes - 2 Hour|
• Feedback individually to students, post-assessment
There will be a series of class assignments that will be submitted, graded and returned to the students at a tutorial session. For the spectroscopy section of the course there will be an assignment on 1) Mass Spectrometry; 2) IR/UV-Vis Spectroscopy); 3) NMR spectroscopy 1 and 4) NMR spectroscopy 2.
|Professor Patrick Guiry||Lecturer / Co-Lecturer|
|Dr Eoghan McGarrigle||Lecturer / Co-Lecturer|