CHEM30200 Carbonyl Chemistry, Retrosynthesis and Synthetic Methods

Academic Year 2021/2022

This module advances the concepts of the chemical reactivity of the carbonyl group and hetroaromatic compounds with a specific emphasis placed on gaining an understanding of their different modes of reaction. In addition retrosynthetic analysis is introduced and a wide range of chemical transformations important in organic synthesis are discussed. This includes numerous examples of the application of the described chemistry to the making of complex chemical entities. Topic 1: Advanced Carbonyl Chemistry (9 lectures, 2 tutorials). Topic 2: Theory and Application of Retrosynthetic analysis (9 lectures, 2 tutorials). Topic 3: Laboratory Practical Course (8 sessions of 3 hours duration).

Due to the situation we all face with Covid-19 some of this module (Autumn Trimester 2020) will be delivered online. The situation will be assessed on an ongoing basis and as things progress during the summer. Our hope remains that we will deliver as much of this module in a face-to-face fashion, in the coming academic year, as possible.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should have an understanding of:Acidity of Alpha, Beta, Gamma- hydrogens; enolate anion generation, stabilisation; keto/enol tautomerism; halogenation of acetone; alkylation of enolates; regioselctive formation of enolate anions; aldol reactions; claisen reactions; Michael addition chemistry; conjugate addition followed by aldol cyclization; Robinson annelation.Retrosynthetic analysis and how it can be useful in planning synthesis; the application of a range of reactions (nucleophilic substitution, electrophilic aromatic substitution, amide and ester synthesis, addition to carbonyl groups, reactions of nucleophiles with epoxides; reactions of enolates and enols; stereoselective synthesis of alkenes; ring closing and cross metathesis; diels Alder reaction; chemoselectivity and reactions of dianions, reduction of carbonyl compounds; catalytic hydrogenation; oxidation.Laboratory based synthetic organic chemistry with practical and analytical techniques.

Student Effort Hours: 
Student Effort Type Hours
Autonomous Student Learning

54

Lectures

18

Tutorial

4

Laboratories

24

Total

100

Approaches to Teaching and Learning:
Lectures with in-built aspects of student tasks/engagement. Tutorial sessions in the lecture timetable to solve problems related to the course material and as a mechanism to present general feedback to the class. Course relevant laboratory experiments to link to the lecture material and also develop practical skills and use of analytical data to support structure assignment of prepared compounds. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: Written examination 2 hour End of Trimester Exam No Standard conversion grade scale 40% No

60

Continuous Assessment: Four short in-class assessments will be set from the two main lecture material topics over the course of the semester Varies over the Trimester n/a Standard conversion grade scale 40% No

10

Lab Report: Laboratory, continuous assessment Varies over the Trimester n/a Standard conversion grade scale 40% No

30


Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

In semester feedback will be given for the laboratory reports and continuous assessment submitted.

Name Role
Dr Marcus Baumann Lecturer / Co-Lecturer
Assoc Professor Paul Evans Lecturer / Co-Lecturer
Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
 
Autumn
     
Lecture Offering 1 Week(s) - Autumn: All Weeks Mon 09:00 - 09:50
Lecture Offering 1 Week(s) - Autumn: All Weeks Wed 09:00 - 09:50
Laboratory Offering 1 Week(s) - 1, 3 Tues 11:00 - 13:50
Laboratory Offering 1 Week(s) - 2, 4 Tues 11:00 - 13:50
Laboratory Offering 1 Week(s) - 1, 3 Tues 15:00 - 17:50
Laboratory Offering 1 Week(s) - 2, 4 Tues 15:00 - 17:50
Laboratory Offering 2 Week(s) - 1, 3 Tues 11:00 - 13:50
Laboratory Offering 2 Week(s) - 2, 4 Tues 11:00 - 13:50
Laboratory Offering 2 Week(s) - 1, 3 Tues 15:00 - 17:50
Laboratory Offering 2 Week(s) - 2, 4 Tues 15:00 - 17:50
Laboratory Offering 3 Week(s) - 1, 3 Thurs 11:00 - 13:50
Laboratory Offering 3 Week(s) - 2, 4 Thurs 11:00 - 13:50
Laboratory Offering 3 Week(s) - 1, 3 Thurs 15:00 - 17:50
Laboratory Offering 3 Week(s) - 2, 4 Thurs 15:00 - 17:50
Laboratory Offering 4 Week(s) - 1, 3 Thurs 11:00 - 13:50
Laboratory Offering 4 Week(s) - 2, 4 Thurs 11:00 - 13:50
Laboratory Offering 4 Week(s) - 1, 3 Thurs 15:00 - 17:50
Laboratory Offering 4 Week(s) - 2, 4 Thurs 15:00 - 17:50
Autumn