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Curricular information is subject to change
At end of the module students should be able to:
Describe basic structure, properties and reactivity of amino acids and carbohydrates.
Apply the principles of conformational analysis of 'simple' organic molecules to understanding 'folding' in biological molecules. Describe the important reactions and reagents used in synthesis of biological molecules and describe the mechanism by which these reagents work and the usefulness of protecting group strategies. Describe selected chemical transformations of biomolecules. Apply selected physical techniques (NMR, MS) to obtaining information on the structure of biological molecules.
Apply and relate the principles of organic reaction mechanism to processes in biology and relate this to development of small molecules that can be useful as tools for studying biological systems or as drugs. Describe the basics of molecular recognition. Understand the principles of medicinal chemistry.
Perform a series of laboratory techniques and experiments required for synthesis, biotransformations, purification, isolation and (kinetic) analysis of biological molecules.
Carry out these laboratory procedures safely.
Basic structure, properties and reactivity of amino acids, nucleic acids and carbohydrates.
Principles of conformational analysis of 'simple' organic molecules and application to 'folding' of proteins.
Introduction to protecting group chemistry for carbohydrates and amino acids.
Basic reactions and reaction mechanisms for amino acids, nucleic acids and carbohydrates.
Selected chemical transformations of biomolecules (basics of DNA, RNA and protein synthesis).
Use of enzymes as catalysts for organic synthesis.
Use of physical techniques (NMR, MS) to obtaining information on the structure of biological molecules.
Application of principles of organic reaction mechanisms to processes in biology and the development of small molecules that can be useful as tools for studying biological systems or as drugs (e.g., AZT, anti-cancer drugs, anti-oxidants).
The basics of molecular recognition. The principles of medicinal chemistry.
Laboratory techniques: TLC, reduced pressure distillation, rotary evaporation, liquid-liquid separations with sep. funnels, natural product extraction, recording UV spectra and monitoring an enzymatic reaction by UV spectroscopy, protecting group reactions, dipeptide synthesis.
Student Effort Type | Hours |
---|---|
Lectures | 24 |
Tutorial | 4 |
Practical | 24 |
Specified Learning Activities | 8 |
Autonomous Student Learning | 48 |
Total | 108 |
This module requires an understanding of basic organic chemistry. CHEM10050 is required.
Learning Recommendations:CHEM20040
Description | Timing | Component Scale | % of Final Grade | ||
---|---|---|---|---|---|
Not yet recorded. |
Resit In | Terminal Exam |
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Autumn | Yes - 2 Hour |
• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
Feedback will be given on Lab reports by return of the report with annotations and laboratory demonstrators will give oral feedback to groups and/or individuals. Feedback will be given on homework assignments by tutors by return of the assignments with written annotations and tutors will give oral feedback to groups during tutorials.
Name | Role |
---|---|
Assoc Professor Eoghan McGarrigle | Lecturer / Co-Lecturer |
Professor Stefan Oscarson | Lecturer / Co-Lecturer |
Miss Vanessa Becker | Tutor |
Bodhayan Biswas | Tutor |
Mr Ruairi Crawford | Tutor |
Camilla Di Girolamo | Tutor |
Mr Kacper Kluza | Tutor |
Ms Aoife Martin | Tutor |
Mr Fionn McNeill | Tutor |
Ms Dairine Morgan | Tutor |
Mr Paul Nolan | Tutor |
Kathryn Yeow | Tutor |