BIOC40030 Advanced Cell Signalling

Academic Year 2022/2023

This module will be an advanced course on mechanisms of intracellular signalling in higher eukaryotic systems and is core for stage 4 of the B.Sc degree in Biochemistry. The course will focus on detailed consideration of the modes of signalling and mechanisms of desensitization by G protein coupled receptors through the heterotrimeric G proteins and downstream effectors. In addition, the course will focus on key mechanisms and pathways of signalling by members of the monomeric low molecular mass guanine nucleotide binding proteins (LMMGPs) including the Ras, Rho, Rab, ARF/Sar and Ran subfamilies; on regulation, transactivation and integration of those signalling cascades by receptor tyrosine kinase- and GPCR-regulated systems. Particular attention is paid to evaluating the structure/function relationship of the key signalling components and to the integration of the various signalling cascades.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to:
- Discuss the key modes of intracellular signalling in higher eukaryotes.
- Explain the diversity of signalling modalities within complex signalling cascades.
- Critically evaluate key molecular approaches to investigate mechanisms of intracellular signalling in higher eukaryotes.
- Critically evaluate recent advances in intracellular signalling in higher eukaryotes.

Student Effort Hours: 
Student Effort Type Hours
Lectures

12
Autonomous Student Learning

90
Total

102
Approaches to Teaching and Learning:
The main modes of Indicative learning on this course will be
Lectures;
Reflective learning;
Detailed course notes;
Suggested reading lists;
Q&A type tutorial
 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: Written exam, duration 2 hr. 2 hour End of Trimester Exam No Standard conversion grade scale 40% No

100

Carry forward of passed components
Yes
 
Resit In Terminal Exam
Summer Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

In the event that a student as a query, he/she contact the MC who in turn will provide a written comment or meet the student in person at an agreed date and time.

Name Role
Assoc Professor John Crean Lecturer / Co-Lecturer
Dr Mario Manresa Lecturer / Co-Lecturer
Dr Maria Prencipe Lecturer / Co-Lecturer
Dr Helen Reid Tutor