Learning Outcomes:
On completion of this module, students should be able to:
1. Develop a deeper understanding and appreciation of the role of proteins and enzymes in a variety of biochemical processes; 2. Characterise the function of various proteins in physiological processes and disease; 3. Develop competencies in self-directed group learning and presentation skills
Indicative Module Content:
Lecture list:
1 Module Intro
2 Transport across membranes - introduction
3 ABC transporters
4 SLC transporters, nutrient transport
5 Transporters in the brain
6 Transporter research - a biochemist's approach
7 Protein structure – CFTR and Haemoglobin
8 Protein mis-folding and accumulation: Alzheimer’s disease, prion diseases
9 Heat shock proteins and their role in diseases: (immunodominant antigen in infection; role in autoimmune disease)
10 Subject presentation - Biochemistry
11 Serine proteases and Blood clotting
12 Proteomics and protein research
13 The Cell Cycle: regulation by protein kinases and phosphatases
14 Cell Cycle checkpoints in regulation of cell division
15 DNA Damage & Repair pathways in health and disease
16 Circadian Clock and Cell Cycle: interconnected biological circuits
17 Stem cells and Stem cell differentiation
18 Antibodies – Immunotherapies. Antibodies as research tools
19 Diagnostic proteins and peptides in human disease
20 Fluorescent proteins and applications
21 Peptides as biotherapeutics
22 Recombinant proteins and peptides. Bioprocessing