Learning Outcomes:
On completion of this module students should be able to:
1) Discuss the structure and function of vertebrate genomes using diagrams where appropriate
2) Understand genome variation and describe molecular methods used for genetic identification and how these can be applied in animal science and the livestock and food industries.
3) Outline the molecular machinery controlling gene expression in complex eukaryotes and describe the molecular and evolutionary basis of parental/genomic imprinting, providing examples from a range of mammalian species.
3) Outline, using diagrams where appropriate, the molecular genetic control of development in eukaryotes using Drosophila melanogaster as a model.
4) Describe, using examples, how molecular genetic maps can be used to hunt for single genes or quantitative trait loci (QTLs) of economic or veterinary importance in livestock species.
5) Understand the principles underlying genomic selection and its application to animal breeding and livestock improvement.
Indicative Module Content:
This module provides a detailed overview of modern genetics and genomics as it relates to animal science and livestock production. The material complements animal breeding modules by providing a molecular framework for the statistical and theoretical underpinnings of animal breeding and quantitative genetics. The module consists of the following: 1) Basic structural genomics - the organisation and 'geography' of vertebrate genomes. 2) Genetic markers, genetic identification and DNA profiling, practical applications of genetic identification for animal production and the food industries. 3) Transcriptional and translational mechanisms controlling gene expression. 4) Genomic imprinting and other epigenetic phenomena. 5) The molecular genetic control of morphogenesis and pattern formation in eukaryotes. 6) Livestock genomics and genome mapping: the hunt for single genes and quantitative trait loci (QTLs) of economic and veterinary importance. 7) Genetic association studies to identify QTLs underlying production and health traits. 8) Genomic selection and the application of genome information to animal breeding and livestock improvement.