Learning Outcomes:
1. Describe the mechanisms and clinical consequences of abnormalities of chromosome number and structure.
2. Identify inheritance patterns and demonstrate the implications for other family members with risk calculations.
3. Demonstrate the consequences of specific disease causing variants and epigenetic alterations in selected inherited conditions.
4. Demonstrate an understanding of the genetic susceptibility to common diseases
5. Demonstrate an awareness of the role of genomics in medicine and the use of molecular techniques in the diagnosis of inherited conditions and cancer.
6. Describe the structure of prokaryotic cells and define the function of its structures.
7. Discuss the means by which microorganisms exist in association with humans and their environment and discuss how they gain access to tissues and cause disease.
8. Explain the epidemiology of infectious diseases and describe the basis of prevention and treatment of microbial diseases.
9. Appreciate the role of the microbiologist and the laboratory in the diagnosis and management of microbial disease
10. Distinguish benign and malignant tumours (grossly and microscopically) with particular consideration to the differences between epithelial, soft tissue and haematological cancers.
11. Understand the molecular changes in tumours (cell cycle, proliferation, genomic integrity) and the principles of invasion and metastasis.
12. Discuss the differences between sporadic and hereditary cancers (the roles of proto oncogenes and tumour suppressor genes) and demonstrate the chemical, physical and viral causes of cancer.