GENE40090 Epigenetics

Academic Year 2024/2025

This module will cover advanced topics in epigenetic control including: genomic imprinting, chromatin remodelling and the ‘histone code’, non-coding RNAs, DNA methylation and environmental epigenetics. The module will include discussion on the role of epigenetic modulation in health and disease.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module, students should be able to:
1. Critically evaluate recent research findings in epigenetics;
2. Discuss recent technological approaches used to analyse and modify epigenetic regulation;
3. Describe the experimental approaches that are used in the planning of experiments in epigenetic research.

Indicative Module Content:

Lecture 1: How to write a research plan (NO’S)
Lecture 2: Introduce key concepts in epigenetics (NO’S)
Lecture 3: DNA methylation and gene expression (GB)
Lecture 4: Chromatin remodelling and ‘the histone code’ (GB)
Lecture 5: Non-coding RNAs (GB)
Lectures 6+7: Mini-symposium, 3 speakers presenting their epigenetic research (25 minutes each plus questions)
Lecture 8+9: Cancer epigenetics (AP)
Lecture 10: Tutorial session to review grant application work in progress (NO’S)
Lectures 11+12: Transgenerational epigenetics (RM)

Student Effort Hours: 
Student Effort Type Hours
Lectures

12
Autonomous Student Learning

102
Total

114
Approaches to Teaching and Learning:
The aim of this module is to focus on the most up-to-date epigenetic research which will be delivered through lectures, research presentations by successful scientists in the field and self-directed reading of suggested papers by the students themselves.
Another goal of the module is to develop 'real world' skills required of genetics researchers. Through the research plan, students will learn how to craft a research proposal similar to an Irish Research Council application including writing a lay abstract, research design and consideration of timelines. There will be an initial class with the module coordinator who will go into the detail of how to undertake this and a tutorial class in the last week of the module at which students can raise any issues or queries they might be having. 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Exam (In-person): Short answer questions based on material covered in the lectures. End of trimester
Duration:
1 hr(s)
 Alternative linear conversion grade scale 40% No

25

 No
Assignment(Including Essay): Research Plan detailing a proposed novel research project to address an area of epigenetic study. Week 12 Alternative linear conversion grade scale 40% Yes

75

 Yes

Carry forward of passed components
Yes
 
Resit In Terminal Exam
Autumn Yes - 1 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, on an activity or draft prior to summative assessment
• Peer review activities
• Self-assessment activities

How will my Feedback be Delivered?

Using PeerScholar, you will receive feedback on 2 drafts of your research plan prior to final submission. You will also see drafts written by some of your classmates on which you will comment. Within the tutorial classes you will have the opportunity to ask and receive feedback on your individual research report draft.

Name Role
Dr Gary Brennan Lecturer / Co-Lecturer
Professor Geraldine Butler Lecturer / Co-Lecturer
Dr Rainer Melzer Lecturer / Co-Lecturer
Assoc Professor Antoinette Perry Lecturer / Co-Lecturer