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CHEN40090

Academic Year 2024/2025

Bioprocessing Laboratory (CHEN40090)

Subject:
Chemical Engineering
College:
Engineering & Architecture
School:
Chem & Bioprocess Engineering
Level:
4 (Masters)
Credits:
5
Module Coordinator:
Assoc Professor Susan McDonnell
Trimester:
Spring
Mode of Delivery:
On Campus
Internship Module:
No
How will I be graded?
Letter grades

Curricular information is subject to change.

This module will provide student with an overview of the commercial production of biopharmaceuticals in a GMP facility. Students will also gain understanding of the processes involved in both upstream (cell culture and growth in bioreactor) and downstream (harvest to fill-finish) production of biopharmaceuticals.

A non-standard mark-to-grade conversion system is used in this module for grades of C- and above (i.e. C-: 50.00-54.99; C: 55.00-59.99; C+: 60.00-64.99; B-: 65.00-69.99; B: 70.00-74.99; B+: 75.00-79.99; A-: 80.00-84.99; A: 85.00-89.99; A+:90.00-100.00).

About this Module

Learning Outcomes:

On completion of this module students should be able to:

1. Describe the general layout of an industrial biopharmaceutical facility
2. To identify the utilities and equipment required for production of biopharmaceuticals.
3. Describe the cleaning-in-place (CIP) and steam-in-place (SIP) protocols for setting up a stainless-steel bioreactor.
4. Measure the growth and viability of CHO cells manually and using an automated cell counter.
5. Measure the rate of glucose and lactate metabolism in CHO cells in culture.
6. Understand the steps involved in downstream processing of biopharmaceuticals in particular ultrafiltration and centrifugation.
7. Understand the steps involved in packing a large-scale chromatography unit.


Indicative Module Content:

Students will complete 6 experiments in NIBRT
1. Facilities
2. Cell Culture
3. Bioreactor SIP
4. Packing a large-scale chromatography column
5. Ultrafiltration
6. Disc stack centrifuge

Student Effort Hours:
Student Effort Type Hours
Laboratories

24
Autonomous Student Learning

96
Total

120

Approaches to Teaching and Learning:
Lab-work

Requirements, Exclusions and Recommendations
Learning Requirements:

Student should have successfully completed CHEN40040 Animal Cell Culture Technology OR MICR40020 Micro and Animal Cell Products in Semester 1


Module Requisites and Incompatibles
:
-

Additional Information:
CHEN40040 OR MICR40020 must be completed in Semester 1 before registering for this module


 

Assessment Strategy  
Description Timing Component Scale Must Pass Component % of Final Grade In Module Component Repeat Offered
Report(s): Students must complete 4 lab reports based on NIBRT Training Week 10 Other No

50

 No
Exam (Online): MCQ exam based on NIBRT laboratory sessions Week 14 Other No

30

 No
Participation in Learning Activities: Cell Culture online Training Week 10 Pass/Fail Grade Scale No

10

 No
Practical Skills Assessment: Bioreactor online training Week 11 Pass/Fail Grade Scale No

10

 No

Carry forward of passed components
Yes
 

Resit In Terminal Exam
Summer No
Please see Student Jargon Buster for more information about remediation types and timing. 

Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

Not yet recorded.

Name Role
Professor Niall Barron Lecturer / Co-Lecturer
Dr Colin Clarke Lecturer / Co-Lecturer
Assoc Professor Susan McDonnell Lecturer / Co-Lecturer
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