Learning Outcomes:
Upon completion of this module, students will be expected to be able to discuss and explain parallelisms between chemical reactions and enzymatic ones, protein production, purification and immobilization techniques, they will have an understanding of how mutagenesis can be applied to investigate enzymes mechanism and substrate recognition. Further, the students will be expected to be able to apply basic and advanced concepts in protein engineering and design and should be able to explain the use of different bio-orthogonal chemical reactions for protein modifications. The students will learn about the different types of glycoconjugates and carbohydrates that are found in nature, and their synthesis, structure and biological function. They will also understand the principles of protein architecture and the principles behind intervening in some of the biological processes involving carbohydrate-protein interactions and, accordingly, have the ability to recognize the rationale behind the design of drug and vaccine candidates. The students will be expected to understand the positives and negatives of different approaches to library generation and have a comprehensive understanding of how these approaches are utilised.