CNWY41160 Statistical Analysis of Proteomic Mass Spectrometric Protein Identification Data

Academic Year 2023/2024

To learn how to use modern mass spectrometric protein analysis tools in biological and medical research.

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Curricular information is subject to change

Learning Outcomes:

- Using the programme MaxQuant to identify and quantify proteins from mass spectrometric data
- Using the programme Perseus to correctly analyse protein expression profiles on a statistical basis
- Using the programme Perseus to correctly analyse protein phosphorylation patterns on a statistical basis
- Learning to recognise data quality limits that can render a statistical analysis impossible
- Learning how to use Data Independent Analysis techniques (DIA) to increase reproducibility in mass spectrometric experiments
- Learning how to use DIA-NN to analyse DIA data
- Differentiating between the requirements in the analysis of protein identification data, clinical and protein modification data

Student Effort Hours: 
Student Effort Type Hours
Lectures

6
Specified Learning Activities

8
Autonomous Student Learning

26
Total

40
Approaches to Teaching and Learning:
Peer work, group work 
Requirements, Exclusions and Recommendations
Learning Requirements:

-.Basic understanding why a statistical analysis is required
-.Basic understanding what a statistical test is
-.Basic understanding what a p-value is


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Attendance: Using the programmes presented on their own computer 2 hour End of Trimester Exam n/a Pass/Fail Grade Scale Yes

100

Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring No
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Peer review activities

How will my Feedback be Delivered?

During the practical part of the course

Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.
 

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